Weight Loss, Exercise, or Both and Physical Function in Obese Older Adults

作者: Dennis T. Villareal , Suresh Chode , Nehu Parimi , David R. Sinacore , Tiffany Hilton

DOI: 10.1056/NEJMOA1008234

关键词:

摘要: BackgroundObesity exacerbates the age-related decline in physical function and causes frailty older adults; however, appropriate treatment for obese adults is controversial. MethodsIn this 1-year, randomized, controlled trial, we evaluated independent combined effects of weight loss exercise 107 who were 65 years age or obese. Participants randomly assigned to a control group, weight-management (diet) an weight-management-plus-exercise (diet–exercise) group. The primary outcome was change score on modified Physical Performance Test. Secondary outcomes included other measures frailty, body composition, bone mineral density, specific functions, quality life. ResultsA total 93 participants (87%) completed study. In intention-to-treat analysis, Test, which higher scores indicate better status, increased more diet–exercise group tha...

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