Three branches to rule them all? UPR signalling in response to chemically versus misfolded proteins-induced ER stress.
作者： Timothy J. Bergmann , Maurizio Molinari
关键词:
摘要: Study of the unfolded protein responses (UPR) is mainly addressed by challenging eukaryotic cells with chemical compounds that impair calcium, redox or glycan homeostasis. These dramatically alter endoplasmic reticulum (ER) environment and function, but also trigger pleiotropic effects may result in multi-organellar failure cell death. Recent works showed UPR induced accumulation polypeptides ER lumen drastically differs from chemically UPR. Unfolded proteins are tolerated cells, which activate a finely tuned without entering apoptotic programs. How adapt to burden misfolded proteins, what structural features accumulating determine intensity how these mechanisms translate into disease crucial questions be address future.
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