Systems Genetics of Liver Fibrosis.
作者： Rabea A. Hall , Frank Lammert
DOI: 10.1007/978-1-4939-6427-7_21
关键词:
摘要: This systems genetics analysis comprises quantitative measurements of hepatic fibrogenesis in mouse models and mapping traits genetic reference populations. It is part a large project fibrogenic genes including the analyses experimental crosses from different inbred strains. Extensive trait loci (QTL) fibrosis phenotypes liver expression profiling combination with silico facilitated identification QTL regions underlying candidate that confer susceptibility also humans. Moreover, approach led to interacting QTLs gene networks fibrosis, providing key platform for development novel, more precise therapeutic interventions. Here, we provide use case application tools integration multiple datasets determined F2 intercrosses BXD recombinant lines identify, finemap affirm loci.
springer.com
sci-hub.se 参考文章(36)
Anita Arslanow, Caroline S. Stokes, Susanne N. Weber, Frank Grünhage, Frank Lammert, Marcin Krawczyk, The common PNPLA3 variant p.I148M is associated with liver fat contents as quantified by controlled attenuation parameter (CAP). Liver International. ,vol. 36, pp. 418- 426 ,(2016) , 10.1111/LIV.12937
Rohit Loomba, Nicholas Schork, Chi-Hua Chen, Ricki Bettencourt, Ana Bhatt, Brandon Ang, Phirum Nguyen, Carolyn Hernandez, Lisa Richards, Joanie Salotti, Steven Lin, Ekihiro Seki, Karen E. Nelson, Claude B. Sirlin, David Brenner, Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study Gastroenterology. ,vol. 149, pp. 1784- 1793 ,(2015) , 10.1053/J.GASTRO.2015.08.011
Thierry Poynard, Vlad Ratziu, Yves Benmanov, Vincent Di Martino, Pierre Bedossa, Pierre Opolon, Fibrosis in Patients with Chronic Hepatitis C: Detection and Significance Seminars in Liver Disease. ,vol. 20, pp. 0047- 0056 ,(2000) , 10.1055/S-2000-9258
Rabea A Hall, Roman Liebe, Katrin Hochrath, Andrey Kazakov, Rudi Alberts, Ulrich Laufs, Michael Böhm, Hans-Peter Fischer, Robert W Williams, Klaus Schughart, Susanne N Weber, Frank Lammert, None, Systems Genetics of Liver Fibrosis: Identification of Fibrogenic and Expression Quantitative Trait Loci in the BXD Murine Reference Population PLoS ONE. ,vol. 9, pp. e89279- ,(2014) , 10.1371/JOURNAL.PONE.0089279
Tom H. Karlsen, Frank Lammert, Richard J. Thompson, Genetics of liver disease: From pathophysiology to clinical practice. Journal of Hepatology. ,vol. 62, ,(2015) , 10.1016/J.JHEP.2015.02.025
Thomas A. Wynn, Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases Journal of Clinical Investigation. ,vol. 117, pp. 524- 529 ,(2007) , 10.1172/JCI31487
Rebecca Taub, Liver regeneration: from myth to mechanism Nature Reviews Molecular Cell Biology. ,vol. 5, pp. 836- 847 ,(2004) , 10.1038/NRM1489
Wajahat Z Mehal, John Iredale, Scott L Friedman, Scraping fibrosis: Expressway to the core of fibrosis Nature Medicine. ,vol. 17, pp. 552- 553 ,(2011) , 10.1038/NM0511-552
Rajiv Jalan, Emerging trends in hepatology: 30 years of the Journal of Hepatology and 50 years of EASL Journal of Hepatology. ,vol. 62, ,(2015) , 10.1016/J.JHEP.2015.03.002
Hongjin Huang, Mitchell L. Shiffman, Scott Friedman, Ramasubbu Venkatesh, Natalie Bzowej, Olivia T. Abar, Charles M. Rowland, Joseph J. Catanese, Diane U. Leong, John J. Sninsky, Thomas J. Layden, Teresa L. Wright, Thomas White, Ramsey C. Cheung, A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C Hepatology. ,vol. 46, pp. 297- 306 ,(2007) , 10.1002/HEP.21695