Systems Genetics of Liver Fibrosis: Identification of Fibrogenic and Expression Quantitative Trait Loci in the BXD Murine Reference Population
作者： Rabea A Hall , Roman Liebe , Katrin Hochrath , Andrey Kazakov , Rudi Alberts
DOI: 10.1371/JOURNAL.PONE.0089279
关键词:
摘要: The progression of liver fibrosis in response to chronic injury varies considerably among individual patients. underlying genetics is highly complex due large numbers potential genes, environmental factors and cell types involved. Here, we provide the first toxicogenomic analysis induced by carbon tetrachloride murine ‘genetic reference panel’ recombinant inbred BXD lines. Our aim was define core risk genes gene interaction networks that control progression. Liver phenotypes expression profiles were determined 35 Quantitative trait locus (QTL) identified seven genomic loci influencing (pQTLs) with genome-wide significance on chromosomes 4, 5, 7, 12, 17. Stepwise refinement based QTL mapping stringent selection criteria, reducing number 1,351 candidate located pQTLs a final list 11 cis-regulated genes. findings demonstrate population represents powerful experimental resource for shortlisting within regulatory network determine liver's vulnerability injury.
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