Liver fibrosis: a compilation on the biomarkers status and their significance during disease progression.

摘要: Liver fibrosis occurs in response to different etiologies of chronic liver injury. Diagnosing degree is a crucial step evaluation severity the disease. An invasive biopsy gold standard method associated with pain and complications. Biomarkers detect include direct markers extracellular matrix turnover indirect as reflection dysfunction. Although single marker may not be useful for successful management, mathematical equation combining tests might effective. The main purpose this review understand diagnostic accuracy biomarkers scoring systems fibrosis. Advances -omics approach have generated clinically significant biomarker candidates that need further evaluation.