Novel bicyclonucleoside analogues
作者： Satoshi Obika , Takeshi Imanishi
DOI:
关键词:
摘要: Novel bicyclonucleoside analogues having an anti-AIDS activity; and intermediates for the preparation of oligonucleotide excellent antisense or antigene activity being stable in vivo . Specifically, compounds represented by structural formula (I) pharmacologically acceptable salts thereof, wherein R is hydrogen a hydroxyl-protecting group; azido, optionally protected amino, like; B purin-9-yl 2-oxo-1,2-dihydropyrimidin-1-yl group which substituted with member selected from consisting halogeno, C1-C6 alkyl, hydroxyl, mercapto, so on.
google.de 参考文章(28)
Akira Kaji, Method for inhibiting propagation of virus and anti-viral agent ,(1984)
Christopher K. Mirabelli, Lex M. Cowsert, Stanley T. Crooke, David J. Ecker, Antisense oligonucleotides directed to papillomavirus ,(1994)
John Goodchild, Paul C. Zamecnik, Inhibition of htlv-iii by exogenous oligonucleotides ,(1987)
Joseph S. Pagano, Nancy R. Traub, Jung-Chung Lin, Antisense oligonucleotides against Epstein-Barr virus ,(1991)
Muthiah Manoharan, Andrew Mamoru Kawasaki, Phillip Dan Cook, 2'-O-aminooxy-modified oligonucleotides ,(1998)
David J. Ecker, Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides ,(1990)
Lex M. Cowsert, Stanley T. Crooke, Christopher K. Mirabelli, David J. Ecker, Antisense oligonucleotide inhibition of papillomavirus ,(1993)
Robert McKay, Nicholas M. Dean, Brenda Baker, Loren Miraglia, Antisense oligonucleotide compositions and methods for the inibition of c-Jun and c-Fos ,(1997)
Brett P. Monia, Susan M. Freier, David J. Ecker, ANTISENSE OLIGONUCLEOTIDE INHIBITION OF THE ras GENE. ,(1992)
Peter Palese, Sudhir Agrawal, Josef M. E. Leiter, Paul C. Zamecnik, Inhibition of influenza virus replication by oligonucleotide phosphorothioates ,(1990)