Semaphorins as Mediators of Neuronal Apoptosis

摘要: Abstract : Shrinkage and collapse of the neuritic network are often observed during process neuronal apoptosis. However, molecular biochemical basis for axonal damage associated with cell death is still unclear. We present evidence involvement axon guidance molecules repulsive cues in death. Using differential display approach, an up-regulation collapsin response mediator protein was detected sympathetic neurons undergoing dopamine-induced A synchronized induction mRNA secreted collapsin-1 intracellular that preceded commitment to apoptosis detected. Antibodies directed against a conserved collapsin-derived peptide provided marked prolonged protection several types from Moreover, inhibited by antibodies neuropilin-1, putative component semaphorin III/collapsin-1 receptor. Induction also caused exposure III-alkaline phosphatase 293EBNA cells. Anti-collapsin-1 were effective blocking III-induced process. therefore suggest that, before their death, apoptosis-destined may produce secrete destructive can affect neighboring cells thus transfer “death signal” across specific susceptible populations.