Anxiolytic properties of N-acetylcysteine in mice

摘要: Anxiety disorders are highly prevalent and often result in poor quality of life. Available anxiolytics show significant adverse effects as well partial efficacy a sizable part patients. Innovative treatments with more favorable risk-benefit ratio sorely needed. A growing body clinical data indicates the benefits N-acetylcysteine (NAC) psychiatric conditions. NAC modulates antioxidant, glutamatergic, inflammatory neurotrophic pathways central nervous system, all which relevant to anxiety pathology. We evaluated mice models commonly used characterize anxiolytic compounds. Male adult CF1 or BALB/c were treated (i.p.) acutely subacutely (4 consecutive days) (60-150mg/kg) 60min before open field, light/dark, hole-board, social interaction, elevated T-maze stress-induced hyperthermia tests. Diazepam (2mg/kg) was positive control. found that presents models, except for T-maze. Subacute resulted lower effective doses comparison acute treatment. The comparable diazepam. is safe low cost medicine suggested conditions presenting co-morbidity anxiety. This study contributes evidence support validity trials context disorders, especially considering safety profile limitations diazepam long term