Chromatin and Regulation of Gene Expression

摘要: The human genome is approximately three billion nucleotides in composition and, if stretched along a single, continuous strand, would span almost two meters. organization of this entity within the confines nucleus an essential challenge for every eukaryotic cell. Darkly staining nuclear material was observed by early microscopists and called chromatin, which later proved to be structural answer problem. Chromatin structure its place regulated gene expression, cellular homeostasis loss function disease form ever-expanding fundamental interests basic scientists, as well clinicians. This chapter addresses basics chromatin structure, how regulation has been studied, specifics activated, repressed silenced identification remodeling complexes histone modifiers, their functions expression.