Toward an Ensemble View of Chromatosome Structure: A Paradigm Shift from One to Many

摘要: There is renewed interest in linker histone (LH)-nucleosome binding and how LHs influence eukaryotic DNA compaction. For a long time, the goal was to uncover "the structure of chromatosome," but recent studies LH-nucleosome complexes have revealed an ensemble structures. Notably, reconstituted used experiments rarely correspond sequence combinations present organisms. full understanding determinants distribution chromatosome structural ensemble, must include complete description sequences experimental conditions used, be designed enable systematic evaluation environmental effects.