Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy

摘要: Recently, we have shown that the precursor of non-Aβ component Alzheimer’s disease amyloid (NACP), also known as α-synuclein, is a major Lewy bodies (LBs) well neuronal and glial cytoplasmic inclusions in multiple system atrophy (MSA). To elucidate whether accumulation NACP specific to LB MSA, further studied 83 autopsied cases with various neurological disorders, using anti-NACP antibodies. In disease, immunoreactivity was present all LBs neurites both central peripheral nervous systems, pale substantia nigra, dystrophic hippocampal CA2/3 region. Immunoelectron microscopy revealed reaction product localized within filamentous structures associated granular structures. found intracytoplasmic oligodendroglial cells, intranuclear inclusions, swollen processes. No variety other or including Pick’s progressive supranuclear palsy, corticobasal degeneration, motor neuron triplet-repeat diseases. These findings strongly suggest cytopathological feature common MSA.