Prognostic factors and survival in 324 patients with pancreatic endocrine tumor treated at a single institution

摘要: Purpose: Unequivocal pathologic markers for the prognosis of pancreatic endocrine tumors are often lacking. Suggestions prognostic guidance include WHO classification. Recently, a tumor-node-metastasis (TNM) staging system was proposed. We evaluate this system, as well assess other potential factors such tumor Ki67, size, syndrome, heredity, body mass index (BMI), and plasma chromogranin A, in large patient material treated at single institution. Experimental Design: A total 324 patients with tumor, consecutively diagnosed tertiary referral center, were retrospectively evaluated. Median follow-up 54 months (range, 1-423 months). Patient data extracted from medical records. Univariate multivariate analyses done to recognize value. Results: The median overall survival 99 (95% confidence interval, 81-117). Five- 10-year rates 64% 44%, respectively. In univariate analysis, TNM stage, radical surgery, classification, nonfunctioning Ki67 ≥2%, ≥3 times upper normal limit, BMI Conclusions: recently suggested emerged useful clinical tool.