Hematologic Markers of Influenza A H1N1 for Early Laboratory Diagnosis and Treatment Assessment

作者: Nianyue Wang , Xuan Liu , Yongchen Zhang , Yao Xie , Wei Zhao

DOI: 10.1309/LMRVLJY3BRXLZGE3

关键词:

摘要: Background: Influenza A H1N1 has contributed to significant morbidity and mortality, yet very few studies on changes in hematologic biochemical markers have been reported. Methods: The variable characteristics of several laboratory indices were statistically analyzed during the disease course. Results: In incipient stage, RBC platelet counts most patients normal, while total WBC, neutrophils, lymphocytes decreased some cases. hepatic renal function indicators mostly within normal limits, electrolyte imbalance occurred T subgroups significantly acute stage became extremely low a days later, then recovered limits convalescent stage. Conclusions: could be considered as progressive H1N1, which great clinical significance early diagnosis, progression, prognosis evaluation H1N1. This work provided convenient diagnostic criteria for reference. * CDC : Centers Disease Control TB bilirubin TP protein A albumin ALT alanine aminotransferase AST aspartate LD lactate dehydrogenase UN urea CR creatinine RT-PCR reverse transcription polymerase chain reaction PCR SARS severe respiratory syndrome RSV syncytial virus

参考文章(12)
P.A Chan, N.T Connell, A.M Gabonay, B. Westley, J.M Larkin, S.P LaRosa, K. Chapin, L. Mermel, Oseltamivir-resistant 2009–2010 pandemic influenza A (H1N1) in an immunocompromised patient Clinical Microbiology and Infection. ,vol. 16, pp. 1576- 1578 ,(2010) , 10.1111/J.1469-0691.2010.03212.X
Annette B. Vogel, Emanuel Haasbach, Sarah J. Reiling, Karoline Droebner, Karin Klingel, Oliver Planz, Highly Pathogenic Influenza Virus Infection of the Thymus Interferes with T Lymphocyte Development Journal of Immunology. ,vol. 185, pp. 4824- 4834 ,(2010) , 10.4049/JIMMUNOL.0903631
Seung-Hyun Lim, Ju-Hyung Lee, Bu-Chul Kim, Sung-Un Jung, Young-Bae Park, Chang-Seop Lee, Adverse reaction of influenza A (H1N1) 2009 virus vaccination in pregnant women and its effect on newborns Vaccine. ,vol. 28, pp. 7455- 7456 ,(2010) , 10.1016/J.VACCINE.2010.08.087
Alison Bish, Susan Michie, Demographic and attitudinal determinants of protective behaviours during a pandemic: A review British Journal of Health Psychology. ,vol. 15, pp. 797- 824 ,(2010) , 10.1348/135910710X485826
Chen Ming, Xiao Wei, Ai Biao, He Han, Liu Xuezheng, Dong Hong, Xiong Jun, Xu Li, Sensitivity Assessment of Rapid Influenza Diagnostic Tests for the Detection of the 2009 Pandemic Influenza A (H1N1) Virus in Clinical Specimens Labmedicine. ,vol. 41, pp. 731- 734 ,(2010) , 10.1309/LM1SH48AEBLVMJUQ
Lewis Satterwhite, Ashish Mehta, Greg S. Martin, Novel findings from the second wave of adult ph1n1 in the United States Critical Care Medicine. ,vol. 38, pp. 2059- 2061 ,(2010) , 10.1097/CCM.0B013E3181EB96DC
Hector M. Zepeda-Lopez, Lizbeth Perea-Araujo, Angel Miliar-García, Aarón Dominguez-López, Beatriz Xoconostle-Cázarez, Eleazar Lara-Padilla, Jorge A. Ramírez Hernandez, Edgar Sevilla-Reyes, Maria Esther Orozco, Armando Ahued-Ortega, Ignacio Villaseñor-Ruiz, Ricardo J. Garcia-Cavazos, Luis M. Teran, Inside the Outbreak of the 2009 Influenza A (H1N1)v Virus in Mexico PLoS ONE. ,vol. 5, pp. e13256- ,(2010) , 10.1371/JOURNAL.PONE.0013256
Akira Ukimura, Tohru Izumi, Akira Matsumori, Clinical Research Committee on Myoc, A National Survey on Myocarditis Associated With the 2009 Influenza A (H1N1) Pandemic in Japan Circulation Journal. ,vol. 74, pp. 2193- 2199 ,(2010) , 10.1253/CIRCJ.CJ-10-0452
Kendra A. Bussey, Tatiana L. Bousse, Emily A. Desmet, Baek Kim, Toru Takimoto, PB2 Residue 271 Plays a Key Role in Enhanced Polymerase Activity of Influenza A Viruses in Mammalian Host Cells Journal of Virology. ,vol. 84, pp. 4395- 4406 ,(2010) , 10.1128/JVI.02642-09
Francesco Gesualdo, Mariateresa Romano, Elisabetta Pandolfi, Caterina Rizzo, Lucilla Ravà, Daniela Lucente, Alberto E Tozzi, Surfing the web during pandemic flu: availability of World Health Organization recommendations on prevention BMC Public Health. ,vol. 10, pp. 561- 561 ,(2010) , 10.1186/1471-2458-10-561