Pathology of Cardiac Allograft Vascular (Microvascular) Rejection: Impact on Patient Outcomes

摘要: Pathologic descriptions of allograft rejection solid organs have long recognized several forms vascular involvement as part the process. Renal allografts commonly display vasculitis involving arteries and arterioles cortex with or without cellular infiltrates invading tubules in severest acute rejection.1–3 This inflammatory process, often termed rejection, is identified 50% acutely rejecting kidneys frequently associated injury loss spite increased immunosuppressive therapy.2–4 By contrast, arteritis rarely cardiac on endomyocardial biopsy although it has been poor survival.5,6