The Regulation of Lymphocyte Traffic

摘要: The distribution of lymphocytes among the tissues body is not random. Both number and representation particular functional subsets are carefully controlled, differing in each lymphoid organ or tissue a manner that presumably reflects local immune requirements. function lymphocyte class, their previous history stage differentiation, antigenic specificity. For example, those populations primarily responsible for humoral immunity (B cells) predominate spleen gut-associated Peyer’s patches, whereas T cells, which regulatory cytotoxic major type peripheral lymph nodes skin (Stevens et al. 1982; Streilein 1978). Functionally antigenically defined T-cell also unequally distributed between mucosal nonmucosal (Elson 1979; Kraal 1983). certain effector effector-precursor can be even more restricted: especially dramatic segregation IgA- vs. IgG-expressing B cells. Surface IgA-bearing highly represented mucosa-associated organs, surfaces attract predominantly IgA-secreting plasma cells (Guy-Grand 1974; reviewed by Lamm 1976). In sites, such as skin, rare, most secrete IgM IgG. Lymphocytes segregate vivo on basis antigen specificity: antigen-specific disproportionately challenged with (Kraal Sprent 1980) accumulate sites specific deposition (Husband Gowans 1978; Husband 1982).