Role of the Golgi apparatus in cellular pathology

摘要: The Golgi apparatus response to pathological disorders is predominantly as an intermediary component of membrane biogenesis where it involved in processing, sorting and secretion materials via secretory granules, the formation lysosomes. A common initial any stress alteration or cessation activity. In transformed cell, altered both morphologically biochemically, suggesting a shift from membrane-generating mode functioning. However, since fewer less well-developed are frequently found cells, analytical methods isolation developed for normal tissues may not always yield equivalent results when applied tumors. Cell surface alterations characteristic malignant cells result modifications occurring at level apparatus. Some lysosomal dysfunctions underglycosylation acid hydrolases by use cell-free systems between endoplasmic reticulum within cisterane providing new approach elucidation role well states.