Perezone and its isomer isoperezone induce caspase-dependent and caspase-independent cell death.
作者： L.E. Sánchez-Torres , J.A. Torres-Martínez , M. Godínez-Victoria , J.-M. Omar , B. Velasco-Bejarano
DOI: 10.1016/J.PHYMED.2009.12.011
关键词:
摘要: In this study, we investigated the cytotoxic effect of perezone, a constituent isolated from roots Perezia spp. and its synthetic isomer isoperezone on K562 human leukemia cell line. Perezone showed greater than but both compounds were found to induce cytotoxicity trough caspase-dependent caspase-independent mechanisms; important changes in their light scattering properties, phosphatidylserine translocation mitochondrial membrane potential disruption detected by cytometry. The mechanism death induction each compound interesting concentration-dependent differences. Neither induced apoptosis inducing factor.
cabdirect.org
elsevier.com
sci-hub.se 参考文章(18)
A DEPENA, Effect of perezone, aminoperezone and their corresponding isomers isoperezone and isoaminoperezone upon platelet aggregation Phytomedicine. ,vol. 8, pp. 465- 468 ,(2001) , 10.1078/S0944-7113(04)70066-5
M Lamkanfi, N Festjens, W Declercq, T Vanden Berghe, P Vandenabeele, Caspases in cell survival, proliferation and differentiation Cell Death & Differentiation. ,vol. 14, pp. 44- 55 ,(2007) , 10.1038/SJ.CDD.4402047
G Kroemer, L Galluzzi, P Vandenabeele, J Abrams, E S Alnemri, E H Baehrecke, M V Blagosklonny, W S El-Deiry, P Golstein, D R Green, M Hengartner, R A Knight, S Kumar, S A Lipton, W Malorni, G Nuñez, M E Peter, J Tschopp, J Yuan, M Piacentini, B Zhivotovsky, G Melino, Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 Cell Death & Differentiation. ,vol. 16, pp. 3- 11 ,(2005) , 10.1038/CDD.2008.150
Lynne M HOWELLS, Elena P MOISEEVA, Christopher P NEAL, Bethany E FOREMAN, Catherine K ANDREADI, Yi-yang SUN, E Ann HUDSON, Margaret M MANSON, Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals. Acta Pharmacologica Sinica. ,vol. 28, pp. 1274- 1304 ,(2007) , 10.1111/J.1745-7254.2007.00690.X
FJ Alarcon-Aguilar, R Roman-Ramos, M Jimenez-Estrada, R Reyes-Chilpa, B Gonzalez-Paredes, JL Flores-Saenz, None, Effects of three Mexican medicinal plants (Asteraceae) on blood glucose levels in healthy mice and rabbits Journal of Ethnopharmacology. ,vol. 55, pp. 171- 177 ,(1997) , 10.1016/S0378-8741(96)01494-8
Hans Nohl, Werner Jordan, Richard J. Youngman, Quinones in biology: functions in electron transfer and oxygen activation Advances in Free Radical Biology & Medicine. ,vol. 2, pp. 211- 279 ,(1986) , 10.1016/S8755-9668(86)80030-8
R. Enríquez, J. Ortega, X. Lozoya, Active components in Perezia roots. Journal of Ethnopharmacology. ,vol. 2, pp. 389- 393 ,(1980) , 10.1016/S0378-8741(80)81018-X
Richard A Lockshin, Zahra Zakeri, Cell death in health and disease. Journal of Cellular and Molecular Medicine. ,vol. 11, pp. 1214- 1224 ,(2007) , 10.1111/J.1582-4934.2007.00150.X
JoséFrancisco Téllez, Karla Carvajal, David Cruz, Alfonso Cárabez, Edmundo Chávez, None, Effect of perezone on arrhythmias and markers of cell injury during reperfusion in the anesthetized rat Life Sciences. ,vol. 65, pp. 1615- 1623 ,(1999) , 10.1016/S0024-3205(99)00411-7
E. Burgue�o-Tapia, P. Joseph-Nathan, Detailed Studies of Perezone Rearrangements Monatshefte Fur Chemie. ,vol. 128, pp. 651- 658 ,(1997) , 10.1007/BF00807596