Disease progression in Chinese chronic hepatitis C patients with persistently normal alanine aminotransaminase levels
作者： C.-K. HUI , H.-Y. ZHANG , T. SHEK , H. YAO , Y.-H. YUENG
DOI: 10.1111/J.1365-2036.2007.03318.X
关键词:
摘要: Summary Background Although chronic hepatitis C virus-infected patients with persistently normal alanine aminotransaminase levels usually have mild liver disease, disease progression can still occur. However, it is uncertain which group of at risk progression. Aim To examine the severity on biopsy in Chinese levels, and their over time. Methods Eighty-two were followed up longitudinally. The median time follow-up was 8.1 years. Forty-seven 82 (57.3%) had a second biopsy. Results At analysis, six (7.3%) developed decompensated cirrhosis. Patients an initial fibrosis stage F2 or F3 [6/23 (26.1%) vs. 0/59 (0%), P < 0.0001] inflammatory grade A2 A3 [5/40 (12.5%) 1/42 (2.4%), P = 0.04] more likely to develop On multivariate independently associated cirrhosis (relative 2.3, 95% confidence interval 0.03–2.5, P = 0.02). Conclusion Chinese virus moderate severe evaluation are
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