Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.

作者: Li Tan , Jun Wang , Junko Tanizaki , Zhifeng Huang , Amir R. Aref

DOI: 10.1073/PNAS.1403438111

关键词:

摘要: The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation. Resistance usually results from …

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