Sea Urchin Pigments: Echinochrome A and Its Potential Implication in the Cytokine Storm Syndrome.

摘要: Background: Echinochrome A (EchA) is a pigment from sea urchins. EchA polyhydroxylated 1,4-naphthoquinone that contains several hydroxyl groups appropriate for free-radical scavenging and preventing redox imbalance. the most studied molecule of this family an active principle approved to be used in humans, usually cardiopathies glaucoma. as pharmaceutical drug. Methods: comprehensive literature patent search review was undertaken using PubMed, well Google Scholar Espacenet engines these areas. Conclusions: In bloodstream, can mediate cellular responses, act radical scavenger, activate glutathione pathway. It decreases ROS imbalance, prevents limits lipid peroxidation, enhances mitochondrial functions. Most importantly, contributes modulation immune system. regulate generation regulatory T cells, inhibit pro-inflammatory IL-1β IL-6 cytokine production, while slightly reducing IL-8, TNF-α, INF-α, NKT, thus correcting These characteristics suggest candidate drug alleviate storm syndrome (CSS).