Retinal vein occlusion associated with methylenetetrahydrofolate reductase mutation
作者： Anat Loewenstein , Michaela Goldstein , Asher Winder , Moshe Lazar , Amiram Eldor
DOI: 10.1016/S0161-6420(99)90357-3
关键词:
摘要: Abstract Objective To report on the occurrence of methylenetetrahydrofolate reductase (MTHFR) deficiency in patients with retinal vein occlusion (RVO). Design Prospective case series Participants Fifty-nine consecutive newly diagnosed RVO seen at Retina Unit Tel Aviv Medical Center during 1997. Methods/testing Interviews and multiple blood analyses were done. Data compared to reported incidence MTHFR Israeli population large. Results Twenty-six (44.1%) heterozygotes 11 (18.6%) homozygotes for 677C-T mutation MTHFR. The homozygosity was documented as being present 10.4% healthy individuals population. difference found be statistically significant ( P = 0.038). Conclusions Retinal may associated a
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sci-hub.se 参考文章(57)
D G Franken, G H Boers, H J Blom, F J Trijbels, P W Kloppenborg, Treatment of mild hyperhomocysteinemia in vascular disease patients. Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 14, pp. 465- 470 ,(1994) , 10.1161/01.ATV.14.3.465
M. Adams, P.D. Smith, D. Martin, J.R. Thompson, D. Lodwick, N.J. Samani, Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction. QJM: An International Journal of Medicine. ,vol. 89, pp. 437- 444 ,(1996) , 10.1093/QJMED/89.6.437
Marco Cattaneo, Michael Y. Tsai, Paolo Bucciarelli, Emanuela Taioli, Maddalena L. Zighetti, Michelle Bignell, Pier Mannuccio Mannucci, A common mutation in the methylenetetrahydrofolate reductase gene (C677T) increases the risk for deep-vein thrombosis in patients with mutant factor V (factor V:Q506) Arteriosclerosis, Thrombosis, and Vascular Biology. ,vol. 17, pp. 1662- 1666 ,(1997) , 10.1161/01.ATV.17.9.1662
Kostulas, Crisby, Huang, Lannfelt, Hagenfeldt, Eggertsen, Kostulas, Hillert, A methylenetetrahydrofolate reductase gene polymorphism in ischaemic stroke and in carotid artery stenosis European Journal of Clinical Investigation. ,vol. 28, pp. 285- 289 ,(1998) , 10.1046/J.1365-2362.1998.00281.X
G. H. J. Boers, P. Frosst, L. P. W. J. Van Den Heuvel, R. Rozen, E. M. B. Stevens, H. J. Blom, L. A. J. Kluijtmans, F. J. M. Trijbels, M. Den Heijer, B. A. Van Oost, Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. American Journal of Human Genetics. ,vol. 58, pp. 35- 41 ,(1996)
Stephen M. Schwartz, David S. Siscovick, M. Rene Malinow, Frits R. Rosendaal, R. Kevin Beverly, David L. Hess, Bruce M. Psaty, W. T. Longstreth, Thomas D. Koepsell, T. E. Raghunathan, Pieter H. Reitsma, Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene. Circulation. ,vol. 96, pp. 412- 417 ,(1997) , 10.1161/01.CIR.96.2.412
Michael J. Kupferminc, Amiram Eldor, Nitzan Steinman, Ariel Many, Amiram Bar-Am, Ariel Jaffa, Gideon Fait, Joseph B. Lessing, Increased frequency of genetic thrombophilia in women with complications of pregnancy. The New England Journal of Medicine. ,vol. 340, pp. 9- 13 ,(1999) , 10.1056/NEJM199901073400102
P. Frosst, H.J. Blom, R. Milos, P. Goyette, C.A. Sheppard, R.G. Matthews, G.J.H. Boers, M. den Heijer, L.A.J. Kluijtmans, L.P. van den Heuve, R. Rozen, A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase Nature Genetics. ,vol. 10, pp. 111- 113 ,(1995) , 10.1038/NG0595-111
T H Williamson, A Rumley, G D Lowe, Blood viscosity, coagulation, and activated protein C resistance in central retinal vein occlusion: a population controlled study. British Journal of Ophthalmology. ,vol. 80, pp. 203- 208 ,(1996) , 10.1136/BJO.80.3.203
Ottar Nygård, Jan Erik Nordrehaug, Helga Refsum, Per Magne Ueland, Mikael Farstad, Stein Emil Vollset, Plasma Homocysteine Levels and Mortality in Patients with Coronary Artery Disease The New England Journal of Medicine. ,vol. 337, pp. 230- 236 ,(1997) , 10.1056/NEJM199707243370403