Airway inflammation assessed by invasive and noninvasive means in severe asthma: Eosinophilic and noneosinophilic phenotypes

摘要: Background Airway inflammation assessed by bronchial biopsies demonstrates distinct eosinophilic and noneosinophilic phenotypes in severe asthma, but their relationship to other biomarkers of disease (induced sputum nitric oxide [NO]) is not clear. Objectives We sought compare airway using noninvasive sputum, exhaled NO), invasive (bronchial biopsies) methods moderate asthma assess whether induced NO would allow the identification asthma. Methods performed a cross-sectional study 32 subjects with 35 from whom we obtained biopsies, measurements. Results Among identified both cell counts. However, vast majority high eosinophil counts did have mucosal Exhaled was increased phenotype as judged biopsy findings, on basis sputum. Subjects experienced more exacerbations than low In contrast, find any differences clinical characteristics between that were biopsies. Conclusion The use allowed subgroup who at risk frequent exacerbations. Clinical implications Monitoring may identifying greatest activity.