Is Exercise Training Beneficial in Progressive Multiple Sclerosis

摘要: Background There is substantial evidence for the benefits of exercise training in people with multiple sclerosis (MS). These benefits, however, have primarily been established early, relapsing disease phase or are derived from heterogeneous MS samples (ie, and progressive MS). This makes it challenging to determine whether consequences similar courses. The role far less clear. study examined potential MS. Methods We review current studies examining conventional modalities (eg, cycle ergometry) as well specialized approaches functional electrical stimulation cycling) involving exclusively individuals Results reviewed nine trials provides preliminary support regard fitness, symptom, quality life outcomes MS, although these data currently limited at times conflicting. Conclusions Considering prevalence 1 million worldwide), lack effective treatment options, considerable frustration researchers, clinicians, patients, we believe that represents a viable therapeutic option worthy further consideration. Future research should involve well-designed, randomized clinical appropriate sample sizes control conditions establish safety, feasibility, efficacy