Embryo transfer practices and multiple births resulting from assisted reproductive technology: an opportunity for prevention

摘要: Objective To evaluate assisted reproductive technology (ART) ET practices in the United States and assess impact of these on multiple births, which pose health risks for both mothers infants. Design Retrospective cohort analysis using National ART Surveillance System data. Setting US fertility centers reporting to System. Patient(s) Noncanceled cycles conducted in 2012. Intervention(s) None. Main Outcome Measure(s) Multiple birth (birth two or more infants, at least one whom was live-born). Result(s) Of 134,381 transfer performed 2012, 51,262 resulted live 13,563 (26.5%) were births: 13,123 twin 440 triplet higher order births. Almost half (46.1%) births from following four cycle types: fresh blastocyst transfers among favorable average prognosis patients less than 35 years (1,931 1,341 respectively), donor-oocyte recipients (1,532 births), frozen/thawed ETs (1,452 births). More embryos (52.5% autologous transfers, 67.2% recipient 42.9% transfers). Conclusion(s) A substantial reduction ART-related (both order) could be achieved by single age recipients.