Recent Results in Preclinical and Clinical Drug Development of Chemopreventive Agents at the National Cancer Institute

作者: Gary J. Kelloff , Charles W. Boone , Winfred Malone , Vernon Steele

DOI: 10.1007/978-1-4615-2984-2_35

关键词:

摘要: A primary goal of the Chemoprevention Program Division Cancer Prevention and Control (DCPC) at National Institute (NCI) is development safe effective chemopreventive agents. This NCI effort organized as an applied drug science program, with clinical trials final endpoint. The objective this paper to establish a perspective for research in that sponsored by Program, present recent results progress most promising

参考文章(51)
Rumack Bh, Miller Lf, Clinical safety of high oral doses of acetylcysteine. Seminars in Oncology. ,vol. 10, pp. 76- 85 ,(1983)
Niels Arley, Reidar Eker, Mechanisms of Carcinogenesis1 Advances in biological and medical physics. ,vol. 8, pp. 375- 436 ,(1962) , 10.1016/B978-1-4831-9927-6.50011-3
Harold Newmark, Sidney J. Winawer, Martin Lipkin, Eileen Friedman, Colonic Epithelial Cell Proliferation in Responders and Nonresponders to Supplemental Dietary Calcium Cancer Research. ,vol. 49, pp. 248- 254 ,(1989)
Sidney Winawer, Martin Lipkin, Eileen Friedman, Michel Buset, Shanti Swaroop, Inhibition of human colonic epithelial cell proliferation in vivo and in vitro by calcium. Cancer Research. ,vol. 46, pp. 5426- 5430 ,(1986)
Micheline M. Mathews-Roth, Sudha Welankiwar, Prabhat K. Sehgal, Niels C. G. Lausen, Mark Russett, Norman I. Krinsky, Distribution of [14C]Canthaxanthin and [14C]Lycopene in Rats and Monkeys The Journal of Nutrition. ,vol. 120, pp. 1205- 1213 ,(1990) , 10.1093/JN/120.10.1205
Norman I. Krinsky, Micheline M. Mathews-Roth, Sudha Welankiwar, Prabhat K. Sehgal, Niels C. G. Lausen, Mark Russett, The Metabolism of [14C]β-Carotene and the Presence of Other Carotenoids in Rats and Monkeys The Journal of Nutrition. ,vol. 120, pp. 81- 87 ,(1990) , 10.1093/JN/120.1.81
J. Cuzick, M. Baum, Tamoxifen and contralateral breast cancer. The Lancet. ,vol. 326, pp. 282- ,(1985) , 10.1016/S0140-6736(85)90338-1
Zbigniew Walaszek, Malgorzata Hanausek-Walaszek, John P. Minton, Thomas E. Webb, Dietary glucarate as anti-promoter of 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis. Carcinogenesis. ,vol. 7, pp. 1463- 1466 ,(1986) , 10.1093/CARCIN/7.9.1463