Low level of PDZ domain containing 1 (PDZK1) predicts poor clinical outcome in patients with clear cell renal cell carcinoma

摘要: Clear cell renal carcinoma (ccRCC) is the most lethal neoplasm of urologic system. Clinical therapeutic effect varies greatly between individual ccRCC patients, so there an urgent need to develop prognostic molecular biomarkers help clinicians identify patients in early aggressive management. In this study, samples from primary tumor and their corresponding nontumor adjacent tissues (n = 18) were analyzed by quantitative proteomic assay. Proteins downregulated tumors studied GO KEGG pathways enrichment analyses. Six proteins found both annotated with proliferation patients. Of these proteins, PDZK1 FABP1 also involved lipid metabolism pathway. The downregulation was further validated TCGA_KIRC dataset (n = 532) independent set (n = 202). could discriminate recurrence, metastasis prognosis Low level mRNA protein associated reduced overall survival (OS) disease–free (DFS) two sets. univariate multivariate analyses, defined as factor for OS DFS. These findings indicated that low predict poor clinical outcome ccRCC.