Post-translational regulation of signaling mucins
作者： Paul J Cullen
DOI: 10.1016/J.SBI.2011.08.007
关键词:
摘要: Signaling mucins are large transmembrane glycoproteins that regulate signal transduction pathways. Recent advances have shown two major types of post-translational modifications, protein glycosylation and proteolytic processing, play important unexpected roles in regulating signaling mucin function. New O-glycosyltransferases proteases been identified, the structure domain undergoes auto-proteolysis has solved. A picture is beginning to emerge where specific glycosyl modifications regulated processing control adherence properties contribute routing signals
elsevier.com
sci-hub.se 参考文章(58)
Takahiko Matsushita, Shin-Ichiro Nishimura, Novel synthesis of functional mucin glycopeptides containing both N- and O-glycans. Methods in Enzymology. ,vol. 478, pp. 485- 502 ,(2010) , 10.1016/S0076-6879(10)78023-X
S.R. Hull, E.D. Sugarman, J. Spielman, K.L. Carraway, Biosynthetic maturation of an ascites tumor cell surface sialomucin. Evidence for O-glycosylation of cell surface glycoprotein by the addition of new oligosaccharides during recycling. Journal of Biological Chemistry. ,vol. 266, pp. 13580- 13586 ,(1991) , 10.1016/S0021-9258(18)92738-9
Rhett A. Kovall, Stephen C. Blacklow, Mechanistic Insights into Notch Receptor Signaling from Structural and Biochemical Studies Current Topics in Developmental Biology. ,vol. 92, pp. 31- 71 ,(2010) , 10.1016/S0070-2153(10)92002-4
Nabil G. Seidah, What lies ahead for the proprotein convertases Annals of the New York Academy of Sciences. ,vol. 1220, pp. 149- 161 ,(2011) , 10.1111/J.1749-6632.2010.05883.X
Takahiko Matsushita, Reiko Sadamoto, Naoki Ohyabu, Hideki Nakata, Masataka Fumoto, Naoki Fujitani, Yasuhiro Takegawa, Takeshi Sakamoto, Masaki Kurogochi, Hiroshi Hinou, Hiroki Shimizu, Takaomi Ito, Kentarou Naruchi, Hiroko Togame, Hiroshi Takemoto, Hirosato Kondo, Shin-Ichiro Nishimura, Functional neoglycopeptides: synthesis and characterization of a new class of MUC1 glycoprotein models having core 2-based O-glycan and complex-type N-glycan chains. Biochemistry. ,vol. 48, pp. 11117- 11133 ,(2009) , 10.1021/BI901557A
R. Kleene, M. Mzoughi, G. Joshi, I. Kalus, U. Bormann, C. Schulze, M.-F. Xiao, A. Dityatev, M. Schachner, NCAM-Induced Neurite Outgrowth Depends on Binding of Calmodulin to NCAM and on Nuclear Import of NCAM and fak Fragments The Journal of Neuroscience. ,vol. 30, pp. 10784- 10798 ,(2010) , 10.1523/JNEUROSCI.0297-10.2010
Kerry M. Loomes, Hugh E. Senior, Paula M. West, Anthony M. Roberton, Functional protective role for mucin glycosylated repetitive domains. FEBS Journal. ,vol. 266, pp. 105- 111 ,(1999) , 10.1046/J.1432-1327.1999.00824.X
E Tian, Kelly G. Ten Hagen, Recent insights into the biological roles of mucin-type O-glycosylation. Glycoconjugate Journal. ,vol. 26, pp. 325- 334 ,(2009) , 10.1007/S10719-008-9162-4
Colin A. Chavel, Heather M. Dionne, Barbara Birkaya, Jyoti Joshi, Paul J. Cullen, Multiple Signals Converge on a Differentiation MAPK Pathway PLoS Genetics. ,vol. 6, pp. e1000883- ,(2010) , 10.1371/JOURNAL.PGEN.1000883
Denny G.A. Johansson, Bertil Macao, Anders Sandberg, Torleif Härd, SEA domain autoproteolysis accelerated by conformational strain: mechanistic aspects. Journal of Molecular Biology. ,vol. 377, pp. 1117- 1129 ,(2008) , 10.1016/J.JMB.2008.01.050