Review: Genetic manipulation of the rodent placenta

作者: S.J. Renaud , M.A. Karim Rumi , M.J. Soares

DOI: 10.1016/J.PLACENTA.2010.12.017

关键词:

摘要: The principal role of the placenta is maintenance pregnancy and promotion fetal growth viability. use transgenic rodents has greatly enhanced our understanding placental development function. However, embryonic lethality often a confounding variable in determining whether genetic modification adversely affected development. In these cases, it beneficial to specifically manipulate genome. purpose this review summarize available methodologies for specific rodent placenta. By restricting alterations trophoblast lineage, possible gain deeper that perhaps will lead gene-targeted therapies rescue irregular placentation animals or women at high-risk placenta-associated complications.

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