Mutagenic effects of poly (ADP-ribose) polymerase-1 deficiency in transgenic mice.
作者： Henriqueta Louro , Inês Pinheiro , Paula Costa , Carla Sousa , Anabela Dias
DOI: 10.1016/J.MRFMMM.2007.12.003
关键词:
摘要: Abstract Poly (ADP-ribose) polymerase-1 (Parp1) plays a central role in the maintenance of genomic integrity and has been unequivocally associated to DNA base excision repair (BER) but its involvement double-strand break (DSB) pathways remains unclear. In this work, using transgenic Parp1-deficient mice harbouring lacZ reporter gene, we provide vivo evidence that Parp1 contributes prevention deletions/insertions testis following an alkylation insult. response N-Methyl-N-Nitrosurea (MNU) treatment no significant difference mutant frequency (MF) liver could be attributed status, given both Parp1+/+ Parp1−/− showed similar increase overall MF. However, restriction analysis MNU-induced mutants evidenced shift distribution mutations between point testis, not liver, dependent on status. A higher was observed from comparison mice, whereas were significantly affected. Overall, our findings show participates induced by methylating agents organ-specific factors may influence capacity protect against genotoxic damage.
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