Deficient of a Clock Gene, Brain and Muscle Arnt-Like Protein-1 (BMAL1), Induces Dyslipidemia and Ectopic Fat Formation

摘要: A link between circadian rhythm and metabolism has long been discussed. Circadian is controlled by positive negative transcriptional translational feedback loops composed of several clock genes. Among genes, the brain muscle Arnt-like protein-1 (BMAL1) locomotor output cycles kaput (CLOCK) play important roles in regulation rhythmic transcription. In addition to control rhythm, we have previously shown that BMAL1 regulates adipogenesis. metabolic syndrome patients, function dysregulated visceral adipose tissue. addition, analysis SNPs revealed associated with susceptibility hypertension type II diabetes. Furthermore, significant pancreatic β cells proliferation maturation were recently reported. These results suggest energy homeostasis. Therefore, this study, examined whether loss capable inducing syndrome. Deficient Bmal1 gene mice resulted elevation respiratory quotient value, indicating involved utilization fat as an source. Indeed, lack reduced capacity storage tissue, resulting increase levels circulating fatty acids, including triglycerides, free cholesterol. Elevation acids level induced formation ectopic liver skeletal -/- mice. Interestingly, was not observed tissue-specific (liver or muscle) even under high diet feeding condition. led conclude a crucial factor homeostasis, disorders functions lead development