Blood pressure variability and its association with echocardiographic parameters in hypertensive diabetic patients

摘要: Blood pressure (BP) variability is associated with target organ damage in hypertension and diabetes. The 24 h ambulatory blood monitoring (24 h-ABPM) has been proposed as an evaluation for BP using several indexes [standard deviation (SD) of mean BP, coefficient variation (CV), over time (time-rate index)]. We evaluated the association between measured by 24 h-ABPM echocardiographic variables a cross-sectional study 305 diabetic-hypertensive patients. Two groups were defined median (0.55 mmHg/min) time-rate systolic (SBP) index classified low or high variability. Age was 57.3 ± 6.2 years, 196 (64.3 %) female. Diabetes duration 10.0 (5.0–16.2) years, HbA1c 8.2 ± 1.9 %. Baseline clinical characteristics similar (n = 148) (n = 157) groups. Office SBP higher group (139.9 mmHg vs 146.0 mmHg, P = 0.006; 128.3 mmHg 132.9 mmHg, P = 0.019, respectively). Time-rate index, SD CV SBP, (P < 0.001; P < 0.001 P = 0.003, not independently echocardiography’s multiple linear model when adjusting age, 24 h-ABPM, diabetes HbA1c. regression revealed that significant independent determinants septum thickness, relative wall thickness posterior (parameters left ventricular hypertrophy) were: age (p = 0.025; p = 0.010; p = 0.032, respectively) 24 h-SBP (p < 0.001 three parameters). estimated parameters