Plasma DNA Methylation Analysis in Predicting Short-Term Recurrence of Surgical Patients with Non-small Cell Lung Cancer (NSCLC)
作者： Qingqing Ding , Yuan Mu , Shiyang Pan , Yongqian Shu , Shijiang Zhang
DOI: 10.1007/978-90-481-9382-0_7
关键词:
摘要: The purpose of this study was to validate and evaluate the quantification methylated tumor suppressor genes (TSGs) plasma in predicting short-term recurrence surgical patients with NSCLC. Plasma specimens were collected from 54 consecutive NSCLC before after operation, as well 50 cancer-free controls. All cell-free plasmas analyzed for amounts APC RASSF1A by duplex real-time methylation-specific PCR. methylation correlated either or but not age, gender, lymph node invasion, pathologic subtype grade. quantities operation both presented a similar mode reduction non-recurrences unchanged recurrences. independent factor related logistic multivariate modeling. provides useful prognostic biomarker curative-intent surgery.
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