Nitroglycerin is superior to diltiazem as a coronary bypass conduit vasodilator

摘要: Abstract Background: Recent reports of improved radial artery patency have been attributed, in part, to routine use diltiazem prevent vasospasm. However, is costly, and its may be associated with negative inotropic chronotropic side effects. This study compares the vasodilatory properties those nitroglycerin. Methods: In vitro, organ chambers, nitroglycerin were compared matched segments artery, internal thoracic saphenous vein that harvested from same patients (n = 11). The response intravenous or was vivo 10) ultrasonographic measurements diameter. Results: maximum relaxation (100% ± 4%), (96% 3%) significantly greater than (33% 6%, 22% 7%, 34% 5%, respectively; P .046), whereas (1 μmol/L) did not (median effective concentration, 3.7 0.8 nmol/L; .64). vivo, increased diameter 3%, which (3% 0.5%; .001). Conclusion: Nitroglycerin a superior conduit vasodilator more preventing graft spasm diltiazem. should strongly considered as drug choice after coronary bypass grafting. (J Thorac Cardiovasc Surg 1999;117:906-11)