Endocannabinoids, sperm biology and human fertility

摘要: Abstract Aims In this review, we shall summarize the current knowledge on endocannabinoid system (ECS), and its involvement in multifaceted process of male reproduction. particular, discuss role ECS sperm biology Sertoli cell proliferation death, showing how endocannabinoids may regulate spermatogenesis reproductive potential. Data synthesis The available evidence highlights existence a distinctive network, including sex hormones, that warrants successful pregnancy mammals. it appears endocannabinoid-degrading enzyme FAAH (fatty acid amide hydrolase) has central array signals, because controls several steps biology, from motility to capacitation acrosome reaction. Since regulation activity expression by autocrine paracrine factors occur through genomic or non-genomic mechanisms mediated type-1 cannabinoid receptor (CB1R) signaling, also raise concerns about use CB1R agonists (like marijuana) antagonists anti-obesity drug Acomplia®) subjects age. Conclusion Based present data, point out might be novel potentially important target for development next generation therapeutics against infertility. reduced potential seems paralleled defective FAAH, suggesting able enhance, rather than inhibit, useful fertility enhancers.