Trial evaluation of bone marrow derived mesenchymal stem cells (MSCs) transplantation in revival of spermatogenesis in testicular torsion

摘要: Abstract Defective spermatogenesis due to the failure in germ cell proliferation and differentiation is major sign of male infertility pathogenesis; factor involved up half all infertile couples. Testicular torsion an acute vascular event causing rotation pedicle testis, thereby impeding blood flow testis scrotal contents. Azoospermia caused by a common source impotency, which has not been touched this approach, yet. Here, we use capacity mesenchymal stem cells (MSCs), as multipotent adult cells, revive torsion-induced azoospermia. For purpose, MSCs were extracted from rat bone marrow, cultured transplanted into torsioned testis. Germ specific markers (Oct4, Vasa c-Kit) monitored for after transplantation azoospermed This study trial evaluation follow regenerative revival. These approaches can provide powerful tools investigate basic biology reproductive engineering treatment.