Cellular interactions uncouple beta-adrenergic receptors from adenylate cyclase.
作者： G Ciment , J de Vellis
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摘要: C6 glioma cells and B104 neuroblastoma both possess adenylate cyclase activity, but only have beta-adrenergic receptors. However, when cocultured with cells, show a marked decrease in their ability to accumulate adenosine 3', 5'-monophosphate upon stimulation beta receptor agonists. Since receptors cholera toxin-stimulated activities are present C6/B104 cocultures, we conclude that the receptor/adenylate transduction mechanism is uncoupled.
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