Human Growth Hormone Binding Proteins: Regulation and Physiological Significance
作者： Gerhard Baumann , Moises Mercado , Norma Davila , Melissa Shaw , Klaus Amburn
DOI: 10.1007/978-1-4612-2518-8_3
关键词:
摘要: Circulating growth hormone binding proteins (GHBPs) have recently been recognized in a variety of species. Their discovery has added new dimension to the physiology (GH) action. The human high-affinity GHBP, first described 1986 (1, 2), was subsequently found represent soluble ectodomain GH receptor (GH-R) (3). This property attracted considerable attention among basic scientists and clinicians alike. Another circulating lower affinity probably not related GH-R, received less scrutiny remains only partially characterized (4). Comprehensive reviews GHBPs appeared (5, 6); this chapter summarizes salient features focuses on aspects that are potentially relevant reproduction. For full citation reader is referred mentioned reviews.
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