Ovarian cancer: interplay of vitamin D signaling and miRNA action.

摘要: Increasing attention is being devoted to the mechanisms by which cells receive signals and then translate these into decisions for growth, death, or migration. Recent findings have presented significant breakthroughs in developing a deeper understanding of activation repression target genes proteins response various stimuli how they are assembled during signal transduction cancer cells. Detailed mechanistic insights unveiled new maps linear integrated cascades, but multifaceted nature pathways remains unclear. Although layers information added regarding underlying ovarian polymorphisms VDR gene influence its development, this research must be sequentially collected re-interpreted. We divide multi-component review different segments: vitamin D modulates molecular network cells, controlled tumor suppressors oncogenic miRNAs finally signaling regulates miRNA expression. Intra/inter-population variability insufficiently studied better genetics population will helpful getting step closer personalized medicine.