Oxidative stress and lymphocyte persistence: implications in immunotherapy.

摘要: CD8(+) T cells respond to antigen stimulation through a process of activation, division, and differentiation generating large pool activated effector cytolytic lymphocytes (CTLs). Many cancer patients harbor the accordant precursor CTLs capable responding various tumor-associated antigens (TAA). In selected cases, vaccination with these TAA can elicit detectable antitumor responses. Presently, clinical outcome remains inadequate. The lack efficacy may be attributed molecular cellular mechanisms developed by tumors successfully evade host immune system. Some have been identified. It is becoming increasingly apparent that immunotherapy sole objective inducing activation in itself not sufficient fully overcome averting efficient Strategies neutralize tumor-induced suppression parallel antigenic stimulation. Our data show both oxidative stress- antigen-mediated preferential cell death antigen-experienced memory major contributor dysfunction. persistence functional key element for an response affects any protocol. We therefore propose protecting from premature identifying targeting responsible pathway lead substantial enhancement response. this review, we discuss some fundamental factors involved modulation different lymphocyte subsets towards sensitization or resistance stress.