Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.

摘要: Background: Cardiovascular disease (CVD) risk factors are associated with low serum 25 hydroxyvitamin D (25(OH)D) concentrations in observational studies; however, clinical trial findings inconsistent. Objective: We assessed the effect of vitamin supplementation and increased 25(OH)D on CVD a systemic review meta-analysis randomized controlled trials (RCTs). Design: MEDLINE, CINAHL, EMBASE, Google Scholar were searched for RCTs that evaluated cardiovascular outcomes [blood pressure, parathyroid hormone (PTH), high-sensitivity C-reactive protein (hs-CRP), total cholesterol, high density lipoprotein (HDL LDL, respectively), triglycerides, peak wave velocity (PWV) Augmentation Index (AI)] from 1992 through 2017. Meta-analysis was based random-effects model inverse variance method to calculate standardized mean difference (SMD) as sizes, followed by leave-one-out sensitivity analysis. Risk publication bias using Cochrane checklist Begg funnel plots. The systematic is registered CRD42015025346. Results: identified 2341 studies which 81 met inclusion criteria. indicated significant reduction systolic blood pressure (SMD = -0.102 ± 0.04 mmHg, 95% confidence interval (CI), -0.20 -0.03), diastolic -0.07 0.03 CI, -0.14 -0.006), PTH -0.66 0.08 ng/L, -0.82 -0.49), hs-CRP 0.07 mg/L, -0.34 -0.06), cholesterol -0.15 0.06 mmol/L, -0.25 -0.04), LDL -0.10 0.05 -0.003), triglycerides -0.12 -0.23 -0.003) increase HDL 0.09 0.00 0.17) supplementation. These remained analyses lipid profile, PTH, hs-CRP. There no PWV 0.13 m/s, -0.46 0.06, p 0.14) AI -0.09 0.14%, -0.37 0.19, 0.52) supplemented groups. Conclusion: suggest may act protect against improving factors, including elevated dyslipidemia, inflammation.