Detection of hepatitis C virus in thyroid tissue from patients with chronic HCV infection.

摘要: Thyroid dysfunctions are common in chronic hepatitis C virus (HCV) infection. HCV-RNA has been detected by reverse-transcription polymerase chain reaction (PCR) thyroid from HCV infected patients with acquired immunodeficiency syndrome. However, morphological evidence of replication cells immune competent not provided. In situ hybridization and real-time-PCR were used to analyze tissue 11 (3 anti-HCV, serum positive; 8 anti-HCV negative). Genomic antigenomic was the 3 positive at concentrations 2.6 × 104, 1.7 × 104, 8.6 × 103 copies/µg total RNA (genomic) 3.2 × 102, 4.3 × 103 2.9 × 102 (antigenomic). No negative patients. Presence genomic/antigenomic cases confirmed hybridization. Signals observed cytoplasm cells. conclusion, data obtained indicate that may infect The pathogenic implications this finding merit further research. J. Med. Virol. 80:1588–1594, 2008. © 2008 Wiley-Liss, Inc.