Cutting edge: the etiology of autoimmune thyroid diseases
作者： Deirdre Cocks Eschler , Alia Hasham , Yaron Tomer
DOI: 10.1007/S12016-010-8245-8
关键词:
摘要: Significant progress has been made in our understanding of the mechanisms leading to autoimmune thyroid diseases (AITD). For first time, we are beginning unravel these at molecular level. AITD, including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), common affecting thyroid. They have a complex etiology that involves genetic environmental influences. Seven genes shown contribute AITD. The AITD gene discovered, HLA-DR3, is associated with both GD HT. More recently, this association was dissected level when it substitution neutral amino acids Ala or Gln arginine position beta 74 HLA-DR peptide binding pocket specific sequence change causing Non-MHC confer susceptibility can be classified into two groups: (1) immune-regulatory (e.g., CD40, CTLA-4, PTPN22); (2) thyroid-specific genes—thyroglobulin TSH receptor genes. These interact factors, such as infection, likely through epigenetic trigger disease. In review, summarize latest findings on modulation by factors.
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