Arborescent graft polycaprolactone

摘要: The invention discloses an arborescent graft polycaprolactone, and also polycaprolactone-polyethylene glycol copolymer application of the as a drug carrier. In invention, novel is prepared by preparing new epsilon-caprolactone derivative (4-benzyloxy-ethoxy-epsilon-caprolactone; BECL) from 1,4-cyclohexanediol used raw material, then carrying out ring-opening copolymerization on BECL in presence stannous iso-caprylate catalyst, palladium-carbon catalytic hydrogenation to remove benzyl protecting groups obtain polycaprolactone with multiple hydroxyl groups, finally grafting introducing hydrophilic polyethylene chain segments phosgene extender. aqueous medium, hydrophobic shrinks forma core, stretch at periphery, thus forming unimolecular micelle. As carrier, micelle has advantages large capacity good stability.