Nutrition, Epigenetics, and Metabolic Syndrome
作者： Junjun Wang , Zhenlong Wu , Defa Li , Ning Li , Scott V. Dindot
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摘要: Abstract Significance: Epidemiological and animal studies have demonstrated a close link between maternal nutrition chronic metabolic disease in children adults. Compelling experimental results also indicate that adverse effects of intrauterine growth restriction on offspring can be carried forward to subsequent generations through covalent modifications DNA core histones. Recent Advances: methylation is catalyzed by S-adenosylmethionine-dependent methyltransferases. Methylation, demethylation, acetylation, deacetylation histone proteins are performed methyltransferase, demethylase, acetyltransferase, deacetyltransferase, respectively. Histone activities influenced phosphorylation, ubiquitination, ADP-ribosylation, sumoylation, glycosylation. Metabolism amino acids (glycine, histidine, methionine, serine) vitamins (B6, B12, folate) plays key role provision methyl donors for protein methylati...
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