Cellular lipid binding proteins: expression, function, and nutritional regulation.

摘要: The membrane transport and cytosolic solubilization of hydrophobic ligands, including sterols, fatty acids, retinoids, certain carcinogens, are facilitated by a group similar low molecular weight proteins: plasma protein, acid binding proteins, sterol carrier retinoid proteins. cellular content these which establishes the capacity cell to utilize various is determined events regulating transcription translation, e.g., mRNA abundance liver- gut-type FABPs increased dietary fat, translation hepatic FABP appears be stimulated insulin. Functions attributable lipid proteins remain unclear, but data presented that indicate physiological roles in 1) transport, esterification, oxidation, 2) steroidogenesis, 3) uptake, retinaldehyde reduction, retinol esterification. An exciting novel prospect for trafficking prote...