Objective Response to Chemotherapy As a Potential Surrogate End Point of Survival in Metastatic Breast Cancer Patients

摘要: Purpose To assess the validity of objective response to chemotherapy as a surrogate end point for survival in metastatic breast cancer. Patients and Methods We carried out meta-analysis on individual data from 2,126 cancer patients who were enrolled onto 10 randomized trials comparing standard versus intensified epirubicin-containing chemotherapy. Results The was associated with significantly higher tumor rate compared (pooled odds ratio nonresponse, 0.60; 95% CI, 0.51 0.72). regimens also led better (although not significant) ratio, 0.94; 0.86 1.04; P = .22). Tumor highly significant predictor (P < .0001). When introduced Cox model, hazard favor experimental treatment changed 0.94 1.005 (95% 0.91 1.11; .92), indicating that no residual effect sur...