Shizukaol D Isolated from Chloranthus japonicas Inhibits AMPK-Dependent Lipid Content in Hepatic Cells by Inducing Mitochondrial Dysfunction

作者: Rongkuan Hu , Huan Yan , Xiaojiang Hao , Haiyang Liu , Jiarui Wu

DOI: 10.1371/JOURNAL.PONE.0073527

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摘要: … , this plant is used in traditional medicine to treat traumatic injuries, rheumatic arthralgia, fractures, pulmonary tuberculosis, and neurasthenia. The plant … Determination of lactate content …

参考文章(57)
Paul W Caton, Nanda K Nayuni, Julius Kieswich, Noorafza Q Khan, Muhammed M Yaqoob, Roger Corder, Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5 Journal of Endocrinology. ,vol. 205, pp. 97- 106 ,(2010) , 10.1677/JOE-09-0345
Annett Hahn-Windgassen, Veronique Nogueira, Chia-Chen Chen, Jennifer E. Skeen, Nahum Sonenberg, Nissim Hay, Akt Activates the Mammalian Target of Rapamycin by Regulating Cellular ATP Level and AMPK Activity Journal of Biological Chemistry. ,vol. 280, pp. 32081- 32089 ,(2005) , 10.1074/JBC.M502876200
Ping-Lei Fang, Ying-Li Cao, Huan Yan, Li-Li Pan, Shu-Cong Liu, Ning-Bo Gong, Yang Lü, Chang-Xiang Chen, Hui-Min Zhong, Ying Guo, Hai-Yang Liu, Lindenane disesquiterpenoids with anti-HIV-1 activity from Chloranthus japonicus. Journal of Natural Products. ,vol. 74, pp. 1408- 1413 ,(2011) , 10.1021/NP200087D
Mi Zhang, Munekazu Iinuma, Jun-Song Wang, Masayoshi Oyama, Tetsuro Ito, Ling-Yi Kong, Terpenoids from Chloranthus serratus and their anti-inflammatory activities. Journal of Natural Products. ,vol. 75, pp. 694- 698 ,(2012) , 10.1021/NP200968P
B. Brunmair, K. Staniek, F. Gras, N. Scharf, A. Althaym, R. Clara, M. Roden, E. Gnaiger, H. Nohl, W. Waldhausl, C. Furnsinn, Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions? Diabetes. ,vol. 53, pp. 1052- 1059 ,(2004) , 10.2337/DIABETES.53.4.1052
Cong-Mei Cao, Yong Peng, Qing-Wen Shi, Pei-Gen Xiao, Chemical constituents and bioactivities of plants of chloranthaceae. Chemistry & Biodiversity. ,vol. 5, pp. 219- 238 ,(2008) , 10.1002/CBDV.200890020
Nandakumar Sambandam, Michael Steinmetz, Angel Chu, Judith Y. Altarejos, Jason R. B. Dyck, Gary D. Lopaschuk, Malonyl‐CoA decarboxylase (MCD) is differentially regulated in subcellular compartments by 5′AMP‐activated protein kinase (AMPK) FEBS Journal. ,vol. 271, pp. 2831- 2840 ,(2004) , 10.1111/J.1432-1033.2004.04218.X
D. Grahame Hardie, David Carling, The AMP‐Activated Protein Kinase FEBS Journal. ,vol. 246, pp. 259- 273 ,(1997) , 10.1111/J.1432-1033.1997.00259.X
Mayer B Davidson, Anne L Peters, An Overview of Metformin in the Treatment of Type 2 Diabetes Mellitus The American Journal of Medicine. ,vol. 102, pp. 99- 110 ,(1997) , 10.1016/S0002-9343(96)00353-1