Detection and assessment of infectivity of hepatitis E virus in urine

摘要: Background & Aims Hepatitis E virus (HEV) is known to be excreted in the stool but there has been no report of its presence urine. This study investigated HEV RNA and antigen (HEV-Ag) urine possible transmission. Methods Serum samples from patients with chronic or acute infection infected monkeys were tested for viral biochemical markers. Liver kidney biopsies analyzed by histopathology immunohistochemistry. The infectivity was assessed inoculation into monkeys. Results HEV-Ag detected persistently a patient infection. Subsequently, three eight (37.5%) patients, all whom had detectable their also ratio significantly higher than sera feces. parameters routine urinalysis remained within normal ranges hepatitis monkeys, however, pathological changes observed kidneys Furthermore, one two became after another monkey. Conclusions may result injury pose risk detection valuable diagnosis ongoing