JNK Pathway in CNS Pathologies.

摘要: The c-Jun N-terminal kinase (JNK) signalling pathway is a conserved response to wide range of internal and external cellular stress signals. Beside the response, JNK involved in series vital regulatory mechanisms during development adulthood that are critical maintain tissue homeostasis. These include regulation apoptosis, growth, proliferation, differentiation, migration invasion. has diverse functionality cell-tissue specificity, emerged as key player regeneration, tumorigenesis other pathologies. highly active central nervous system (CNS), plays role when cells need cope with pathophysiological insults adulthood. Here, we review implications pathologies CNS. More specifically, discuss some newly identified examples JNK-driven tumor progression glioblastoma, regeneration/repair after an injury, neurodegeneration neuronal cell death. All these new discoveries support CNS reinforce idea potential target reduce their detrimental effects.