An evolutionary portrait of the progenitor SARS-CoV-2 and its dominant offshoots in COVID-19 pandemic.

摘要: Global sequencing of hundreds thousands genomes Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, has continued to reveal new genetic variants that are the key unraveling its early evolutionary history and tracking global spread over time. Here, we present heretofore cryptic mutational spatiotemporal dynamics SARS-CoV-2 from an analysis high-quality genomes. We report likely most recent common ancestor reconstructed through a novel application advancement computational methods initially developed infer tumor cells in patient. This progenitor genome differs first coronaviruses sampled China by three variants, implying none earliest patients represent index case or gave rise all human infections. However, multiple infections USA harbored fingerprint January 2020 later, suggesting was spreading worldwide months before after reported cases COVID-19 China. Mutations offshoots have produced many dominant strains, which episodically Fingerprinting based on mutations reveals same lineage dominated North America for pandemic 2020. There been replacements predominant strains Europe Asia presence high-frequency America. continually updating dashboard evolution trends (http://sars2evo.datamonkey.org/).